Deep brain stimulation of the subthalamic nucleus is a clinically effective tool for treating medically refractory Parkinson’s disease, but its neural mechanisms remain debated. Previous work has demonstrated that STN DBS results in evoked potentials in the primary motor cortex, suggesting that modulation of cortical physiology may be involved in its therapeutic effects. Due to technical challenges presented by high-amplitude DBS artifacts, these EPs are often measured in response to low-frequency stimulation, which is generally ineffective at PD symptom management. This (...) study aims to characterize STN-to-cortex EPs seen during clinically relevant high-frequency STN DBS for PD. Intraoperatively, we applied STN DBS to 6 PD patients while recording electrocorticography from an electrode strip over the ipsilateral central sulcus. Using recently published techniques, we removed large stimulation artifacts to enable quantification of STN-to-cortex EPs. Two cortical EPs were observed – one synchronized with DBS onset and persisting during ongoing stimulation, and one immediately following DBS offset, here termed the “start” and the “end” EPs respectively. The start EP is, to our knowledge, the first long-latency cortical EP reported during ongoing high-frequency DBS. The start and end EPs differ in magnitude and latency, and the end, but not the start, EP magnitude has a significant relationship to ongoing high gamma power during the EP. These contrasts may suggest mechanistic or circuit differences in EP production during the two time periods. This represents a potential framework for relating DBS clinical efficacy to the effects of a variety of stimulation parameters on EPs. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

The number of wars in which modern countries, primarily the United States and Great Britain, have been involved in the past one hundred years might leave the impression that peace movements there are ineffectual. Virtually every war in recent US and UK history has had its corresponding anti-war protests, and there is no record of a peace movement actively stopping an impending significant military action at inception, although evidence exists that peace movements have affected martial policy after the initial stages (...) of a military action. Instead, peace movements seem to elicit ill will and accusations of self-preservation and treason. This paper will show that peace movements are thus censored through a sense of patriotism constructed by those in positions of influence, including government entities and the press. More important, this paper will argue that the reasoning of these pacifist movements and of their detractors can be more clearly understood through application of the work of philosopher G.E.M. Anscombe, particularly her essay “Modern Moral Philosophy,” than through other philosophers such as Richard M. Weaver. (shrink)

This empirical study of Fortune 1000 firms assesses the degree to which those firms have adopted various practices associated with corporate ethics programs. The study examines the following aspects of formalized corporate ethics activity: ethics-oriented policy statements; formalization of management responsibilities for ethics; free-standing ethics offices; ethics and compliance telephone reporting/advice systems; top management and departmental involvement in ethics activities; usage of ethics training and other ethics awareness activities; investigatory functions; and evaluation of ethics program activities. Results show a high (...) degree of corporate adoption of ethics policies, but wide variability in the extent to which these policies are implemented by various supporting structures and managerial activities. In effect, the vast majority of firms have committed to the low cost, possibly symbolic side of ethics management (e.g., adoption of ethics codes and policies, etc.). But firms differ substantially in their efforts to see that those policies or codes actually are put into practice. (shrink)

Even if there were widespread cross-cultural agreement on the normative issues of business ethics, corporate ethics management initiatives (e.g., codes of conduct, ethics telephone lines, ethics offices) which are appropriate in one cultural setting still could fail to mesh with the management practices and cultural characteristics of a different setting. By uncritically adopting widely promoted American practices for managing corporate ethics, multinational businesses risk failure in pursuing the ostensible goals of corporate ethics initiatives. Pursuing shared ethical goals by means of (...) culturally inappropriate management practices, in short, can undermine the effectiveness of ethics management efforts. This article explicates how several important dimensions of culture can influence the effectiveness of common ethics initiatives, and recommends the development and application of a culture-structure contingency analysis in the task of encouraging ethical behavior in global businesses. (shrink)

Sodium monofluoroacetate (1080) is a mammalian pesticide used in different parts of the world for the control of mammalian pest species. In New Zealand it is used extensively and very successfully as a conservation management tool for the control of brushtail possums (Trichosurus vulpecula) – an introduced marsupial that has become a substantial agricultural and conservation management pest. Possums pose a threat to cattle farming in New Zealand as they are a vector for bovine tuberculosis. In protected natural areas, possum (...) browsing is responsible for large scale defoliation of native vegetation. As with many other pesticides, there has been some degree of popular concern about the use of this toxin and its safety, with particular reference to non-target effects. These concerns have been associated with potential non-target effects on human health, and the health of animals of recreational value (e.g., hunting dogs and game animals). This has led to the development of a strong “anti-1080” lobby in New Zealand. In contrast, this study encompasses a science-based risk analysis focusing on the potential risks to non-target native wildlife with a particular focus on chronic toxicity. It finds that there is evidence that 1080 may have endocrine disrupting capabilities (with potential relevance for non-target wildlife) but that this still needs more detailed investigation. This can be clarified by further targeted research. Further research is also needed to test the degradation rates of 1080 and its breakdown products at ecologically-relevant temperatures (i.e., winter stream temperatures – below 11 °C). Such research may demonstrate that some adjustment to 1080 risk management is warranted in New Zealand, or it may help to put to rest the current controversy over the use of this cost effective conservation management tool. (shrink)

Epistemology -- Power I -- Power II -- Subjectivity -- Resistance -- Critique -- Ethics.

Versions and extensions of intuitionistic and modal logic involving biHeyting and bimodal operators, the axiom of constant domains and Barcan's formula, are formulated as structured categories. Representation theorems for the resulting concepts are proved. Essentially stronger versions, requiring new methods of proof, of known completeness theorems are consequences. A new type of completeness result, with a topos theoretic character, is given for theories satisfying a condition considered by Lawvere . The completeness theorems are used to conclude results asserting that certain (...) logics are conservatively interpretable in others. (shrink)

A survey of works on automatic theorem-proving in the ussr 1964-1970. the philosophical problems are not touched.

When clinical services aspire to quality improvement, creative and innovative approaches to old problems are needed to drive such change. Whilst new ef orts should be applauded, information on this topic can be somewhat grey from an ethical and research point of view. Within the mental health profession there is currently an expectation to routinely evaluate care and disseminate i ndings. The notion of service enhancements under the guise of routine practice is an interesting and untested ethical issue. Should clinical (...) innovation continue to enjoy such impunity as patient autonomy is often compromised as they are often compelled to accept treatment under the coercion of mental health legislation? We believe that it should not. All involvement in any form of research is voluntary, thus patients should also have the right to decline participation in quality projects if they wish to do so. (shrink)

Although the model proposed by Thelen and co-authors provides a detailed explanation for the processes underlying reaching, many aspects of it are highly speculative. One of the reasons for this is our lack of knowledge about transformation of a hand movement plan into joint movements. The leading joint hypothesis (LJH) allows us to partially fill in this gap. The LJH offers a possible explanation for the formation of movement and how it may be represented in memory. Our explanation converges with (...) the dynamic model described in the target article. (shrink)

G.E. Moore, more than either Bertrand Russell or Ludwig Wittgenstein, was chiefly responsible for the rise of the analytic method in twentieth-century philosophy. This selection of his writings shows Moore at his very best. The classic essays are crucial to major philosophical debates that still resonate today. Amongst those included are: * A Defense of Common Sense * Certainty * Sense-Data * External and Internal Relations * Hume's Theory Explained * Is Existence a Predicate? * Proof of an External World (...) In addition, this collection also contains the key early papers in which Moore signals his break with idealism, and three important previously unpublished papers from his later work which illustrate his relationship with Wittgenstein. (shrink)

The essays in this collection fall into three groups: the first dealing with phenomenological methods and discussions, the second with applications in the field of literature, the third with applications in the social sciences. The quality and seriousness of the essays is quite uneven. The essays in the first group fail to go beyond a fairly uncritical reading of Husserl, especially in treating the reduction of the natural viewpoint. The crucial failures there effect the second and third sections. Especially in (...) the analyses of literature, the neglect of the context of meanings leads to questionable generalizations. Natanson's frequent criticisms of Sartre's rejection of the transcendental ego suffer from incomplete statement of Sartre's arguments. One wishes that Natanson had prepared a substantial statement of this discussion for the collection, rather than allow scattered brief remarks in several papers to stand alone. Elsewhere as well, brief suggestive passages could have profited from a thorough rewriting.—W. G. E. (shrink)

To state the central argument of this book would be to miss a great deal of the author's achievement. Munz is concerned with tracing the metaphysical foundations of ethics and furthermore the nature and roots of these, and all, metaphysical conceptions. He does all of this in a resolutely original and tough-minded way, exploring alternatives in the fullest possible manner, arguing with great resourcefulness and force. His originality can be seen in his serious and thorough oppositions to classical and contemporary (...) positions. He never scores off straw men, but takes the trouble to develop opposing positions fully so that his argument will strike at the most fundamental and stringent point. Thus, his thesis, that the basic ethical stances of absolute commitment to others and absolute detachment from others, are dialectically interdependent, is honestly and articulately supported. He is to be credited with developing concepts, arguments, and positions which derive their considerable force on their own merits, while encountering a full range of opposition. He has produced a book with which one can disagree, which may puzzle and even seem peculiar, but which must nonetheless be sincerely admired.—W. G. E. (shrink)

Father Abbott has interviewed twelve council Fathers: Cardinals Léger, Suenens, Liénart, Siri, Koenig, Rugambwa, Alfrink, Doepfner and Cushing; Archbishops Cordeiro and Florit ; and Bishop Carter. The book is curiously uneven in both style and depth. At times the question and answer format is used, at times not. When used, it causes the usual interview weakness--superficiality. When a free format is used and a Father's remarks are allowed to stand uninterrupted and unguided, greater depth results. One feels that Father Abbott (...) has allowed his own interests altogether too much influence. On the whole, the book is somewhat unsatisfying to anyone genuinely interested in following the trends and thoughts among the leading figures of Vatican Council II.--W. G. E. (shrink)

In the central chapter of this short work, Dumery shows that the Husserlian reduction cannot be stopped at the level of the constituting ego with its corresponding essences, for this level of intentionality necessarily involves a community of subjects and a world of essences. This multiplicity shows that passivity and dependence are characteristic of even this level and forces us beyond to a fourth level, the transcendent One. In supporting chapters Dumery discusses the philosopher's stance vis-à-vis religion and other areas (...) of human experience, "henology" vs. "ontology" as a philosophic basis for discussing God, and negative theology. He clarifies the classic proofs for God's existence from his own phenomenological viewpoint. The book is admirably lucid and forceful. The translation is very good, though the translator's Introduction is needlessly long and confused for such a short and clear text.—W. G. E. (shrink)

_Zettel, _ an en face bilingual edition, collects fragments from Wittgenstein's work between 1929 and 1948 on issues of the mind, mathematics, and language.

G. E. L. Owen; VIII*—Aristotelian Pleasures, Proceedings of the Aristotelian Society, Volume 72, Issue 1, 1 June 1972, Pages 135–152, https://doi.org/10.1093/ar.

This is a welcome reprint of a book that continues to grow in importance.

Since psychiatry remains a descriptive discipline, it is essential for its practitioners to understand how the language of psychiatry came to be formed. This important book, written by a psychiatrist-historian, traces the genesis of the descriptive categories of psychopathology and examines their interaction with the psychological and philosophical context within which they arose. The author explores particularly the language and ideas that have characterised descriptive psychopathology from the mid-nineteenth century to the present day. He presents a masterful survey of the (...) history of the main psychiatric symptoms, from the metaphysics of classical antiquity to the operational criteria of today. Tracing the evolution of concepts such as memory, consciousness, will and personality, and of symptoms ranging from catalepsy and aboulia to anxiety and self-harm, this book provides fascinating insights into the subjective nature of mental illness, and into the ideas of British, Continental and American authorities who sought to clarify and define it. (shrink)